ABSTRACT
Objective: To discuss the myocardial protection effect of Qishen Yiqi dropping pills on patients with Qi deficiency and blood stasis syndrome after PCI and the control effect and mechanism on cardiac adverse events. Method: One hundred and twenty-five patients were randomly divided into control group (61 cases) and observation group (64 cases) by random number table after PCI. Patients in control group got Tigrillo tablets, 90 mg/time, 2 times/days, aspirin enteric-coated tablets, 100 mg/time, 1 time/day, and bisoprolol fumarate tablets, 5 mg/time, 1 time/day. In addition to the therapy of control group, patients in observation group were also given Qishen Yiqi dropping pills, 0.5 g/time, 3 times/days, 3 days before operation. A course of treatment was 6 months, and follow-up were carried out for 6 months. Before treatment, and at the 24th, 72th hour after treatment, cardiac troponin I (cTnI) and creatine kinase isoenzyme (CK-MB) were detected. During the first week after operation, and at the 6th month after operation, left ventricular ejection fraction (LVEF), settling velocity (SV), wall motion score index (WMSI), percentage of normal myocardium and myocardial perfusion score index (PS) were recorded. After 12 months of the operation, recurrence of angina pectoris, severe arrhythmia, heart failure, revascularization, non-fatal myocardial infarction, cardiogenic death and in-stent restenosis (ISR) were all recorded. During the first week after the operation, and at the 6th month after operation, six-minute walking test (6 MWT), Seattle angina scale (SAQ) and Qi deficiency and blood stasis syndrome were all scored. Before the operation, and at 48 hours and 6 months after operation, levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), plasma soluble intercellular adhesion molecule-1 (sICAM-1), high-sensitivity C-reactive protein (hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA) and endothelin-1 (ET-1) were all detected. Result: At the 24th, 72th hour after treatment, levels of cTnI and CK-MB in control group were lower than those in observation group (Pth hour after operation and the 6th month after operation, levels of TNF-α, IL-6, s ICAM-1 hs-CRP, MDA and ET-1 were lower than those in control group (PPth months after operation, LVEF, SV and percentage of normal myocardium were higher than those in control group (PPPPth month after operation, score of six-minute walking test was higher than that in control group (PPPConclusion: Qishen Yiqi dropping pills has anti-inflammatory and antioxidant effects, and can ameliorate intradermal function, prevent and treat myocardial injury, reduce rate of MACE, relieve symptoms, and improve activity ability and quality of life of patients.
ABSTRACT
Objective: To discuss the clinical effect of modified Yuyetang to type 2 diabetes mellitus (T2DM) combined with coronary heart disease (deficiency of Qi and Yin or phlegm syndrome and stasis syndrome) and the mechanisms of anti-inflammation and anti-oxidation. Method: One hundred and eighteen patients were randomly divided into control group (58 cases) and observation group (60 cases) by random number table. Patients in control group was orally given insulin or special blood glucose for hypoglycemic agents, aspirin enteric-coated tablets, 100 mg/time, 1 time/day. Patients with dyslipidemia got atorvastatin, 10 mg/time, 1 time/day. And patients with hypertension got captopril tablets, 12.5-25.0 mg/time, 1 time/day. In addition to the therapy of control group, patients in observation group were also given modified Yuyetang, 1 dose/day. A course of treatment was 3 months. Before and after treatment, levels of glycated hemoglobin (HbA1c), fasting blood glucose (FPG), 2-hours postprandial glucose (2 hPG), blood lipids triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HLD-C), low-density lipoprotein (LDL-C), apolipoprotein A (ApoA), apolipoprotein B (ApoB), procalcitonin (PCT), homocysteine (Hcy), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and hypersensitive C-reactive protein (hs-CRP), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and 8-Isoprostaglandin F2a (8-ios-PGF2a) were detected, Gensini and traditional Chinese medicine (TCM) syndrome were scored, and electrocardiogram was detected. Result: After treatment, levels of FPG, HbA1c, LDL-C, ApoB, scores of Gensini and TCM syndrome, PCT, Hcy, IL-6, TNF-α and hs-CRP in observation group were all lower than those in control group (PPPPPPConclusion: In addition to hypoglycemic, lipid-lowering and antiplatelet therapies, Modified Yuye decoction can regulate glucose and lipid metabolism of patients with T2DM and coronary heart disease, relieve degree of coronary artery stenosis, with anti-inflammatory and anti-oxidative stress effect.